The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.

@article{Hattori1995TheHH,
  title={The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.},
  author={Akiko Hattori and Masakuni Sawaki and Katsuhiko Enomoto and Naoto Tsuzuki and Hiroshi Isomura and Takahiro Kojima and Y Kamibayashi and Naoki Sugawara and Taketoshi Sugiyama and Michio Mori},
  journal={Carcinogenesis},
  year={1995},
  volume={16 3},
  pages={491-4}
}
We previously reported that LEC rats, which show a spontaneous occurrence of liver injury and hepatocellular carcinoma (HCC), are highly susceptible to chemical carcinogens such as diethylnitrosamine (DEN). Since abnormal copper accumulation in the liver of LEC rats was found to be a cause of liver injury, it is necessary to elucidate whether the carcinogen susceptibility of LEC rats is related to the accumulation of copper in the liver. In this study we have examined the relationship between… CONTINUE READING

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