The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome.

@article{DragonDurey2009TheHF,
  title={The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome.},
  author={Marie-Agn{\`e}s Dragon-Durey and Caroline Blanc and Florence Marliot and Chantal Loirat and Jacques Blouin and Catherine Saut{\`e}s-Fridman and Wolf Herman Fridman and V{\'e}ronique Fr{\'e}meaux-Bacchi},
  journal={Journal of medical genetics},
  year={2009},
  volume={46 7},
  pages={447-50}
}
BACKGROUND Deletion of the complement factor H related 1 (CFHR1) gene is a consequence of non-allelic homologous recombination and has been reported to be more frequent in atypical haemolytic uraemic syndrome (aHUS) patients than in the normal population. Therefore, it is considered a susceptibility factor for the disease. aHUS is associated with hereditary or acquired abnormalities that lead to uncontrolled alternative pathway complement activation. We tested the CFHR1 deletion for association… CONTINUE READING
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