The high fidelity and unique error signature of human DNA polymerase ε

@inproceedings{Korona2011TheHF,
  title={The high fidelity and unique error signature of human DNA polymerase ε},
  author={Dagmara A. Korona and Kimberly G Lecompte and Zachary F Pursell},
  booktitle={Nucleic acids research},
  year={2011}
}
Bulk replicative DNA synthesis in eukaryotes is highly accurate and efficient, primarily because of two DNA polymerases (Pols): Pols δ and ε. The high fidelity of these enzymes is due to their intrinsic base selectivity and proofreading exonuclease activity which, when coupled with post-replication mismatch repair, helps to maintain human mutation rates at less than one mutation per genome duplication. Conditions that reduce polymerase fidelity result in increased mutagenesis and can lead to… CONTINUE READING

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