The high-affinity receptor for immunoglobulin E: a target for therapy of allergic diseases.

@article{Kint1991TheHR,
  title={The high-affinity receptor for immunoglobulin E: a target for therapy of allergic diseases.},
  author={J P Kin{\'e}t and Ulrich Blank and A. Brini and M. Jouvin and Helmut K{\"u}ster and O Mejan and Chisei Ra},
  journal={International archives of allergy and applied immunology},
  year={1991},
  volume={94 1-4},
  pages={51-5}
}
The high-affinity receptor for IgE (Fc epsilon RI) on mast cells and basophils is a tetrameric complex, alpha beta gamma 2. Here we summarize the latest developments on the structure and function of this receptor. By genetic transfer, we have engineered a cell line secreting substantial amounts of a peptide containing exclusively the extracellular domain of the alpha-subunit. This domain by itself is sufficient to mediate high-affinity binding of IgE. Glycosylation and the presence of the other… CONTINUE READING

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