The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.

@article{Venneti2007TheHA,
  title={The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.},
  author={Sriram Venneti and Amy K Wagner and Guoji Wang and Susan L Slagel and Xiangbai Chen and Brian J. Lopresti and Chester A. Mathis and Clayton A Wiley},
  journal={Experimental neurology},
  year={2007},
  volume={207 1},
  pages={118-27}
}
Traumatic brain injury (TBI) is a significant cause of mortality, morbidity, and disability. Microglial activation is commonly observed in response to neuronal injury which, when prolonged, is thought to be detrimental to neuronal survival. Activated microglia can be labeled using PK11195, a ligand that binds the peripheral benzodiazepine receptor (PBR), receptors which are increased in activated microglia and sparse in the resting brain. We compared the binding properties of two PBR ligands… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Rubor, calor, tumor, dolor, functio laesa… or molecular imaging

European Journal of Nuclear Medicine and Molecular Imaging • 2007
View 4 Excerpts
Highly Influenced

Imaging Neuroinflammation – from Bench to Bedside

Journal of clinical & cellular immunology • 2014
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…