The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.

@article{Hauenstein2015TheHS,
  title={The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.},
  author={Arthur V Hauenstein and Liman Zhang and Hao Wu},
  journal={Current opinion in structural biology},
  year={2015},
  volume={31},
  pages={75-83}
}
Inflammasomes are caspase-1 activating, molecular inflammatory machines that proteolytically mature pro-inflammatory cytokines and induce pyroptotic cell death during innate immune responses. Recent structural studies of proteins that constitute inflammasomes have yielded fresh insights into their assembly mechanisms. In particular, these include a crystal structure of the CARD-containing NOD-like receptor NLRC4, the crystallographic and electron microscopy (EM) studies of the dsDNA sensors… CONTINUE READING