The heterozygous Sod2(+/-) mouse: modeling the mitochondrial role in drug toxicity.


Mitochondria have been increasingly implicated in being a crucial subcellular target and amplifying oxidative injury induced by many drugs. Among the major cytoprotective antioxidants is the mitochondrial matrix protein, superoxide dismutase-2 (SOD2). Genetic modification of the expression of SOD2 by transgenic techniques or gene silencing has generated a… (More)
DOI: 10.1016/j.drudis.2008.08.002


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