The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function

@article{Carpenter2015TheHK,
  title={The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function},
  author={Brandon S. Carpenter and Renee L Barry and K. Verhey and Benjamin L. Allen},
  journal={Journal of Cell Science},
  year={2015},
  volume={128},
  pages={1034 - 1050}
}
ABSTRACT GLI transport to the primary cilium and nucleus is required for proper Hedgehog (HH) signaling; however, the mechanisms that mediate these trafficking events are poorly understood. Kinesin-2 motor proteins regulate ciliary transport of cargo, yet their role in GLI protein function remains unexplored. To examine a role for the heterotrimeric KIF3A–KIF3B–KAP3 kinesin-2 motor complex in regulating GLI activity, we performed a series of structure-function analyses using biochemical, cell… Expand
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