The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.

@article{Konrad1995TheHG,
  title={The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.},
  author={Robert J. Konrad and Robert A M Young and Rae D. Record and Ryan M. Smith and P Butkerait and Diarmuid Manning and Leonard Jarett and Bryan A. Wolf},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 21},
  pages={12869-76}
}
Mastoparan, a tetradecapeptide found in wasp venom that stimulates G-proteins, increases insulin secretion from beta-cells. In this study, we have examined the role of heterotrimeric G-proteins in mastoparan-induced insulin secretion from the insulin-secreting beta-cell line beta-TC3. Mastoparan stimulated insulin secretion in a dose-dependent manner from digitonin-permeabilized beta-TC3 cells. Active mastoparan analogues mastoparan 7, mastoparan 8, and mastoparan X also stimulated secretion… CONTINUE READING

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