The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis.

  title={The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis.},
  author={Borna M{\"u}ller and S{\`o}nia Borrell and Graham Rose and S{\'e}bastien Gagneux},
  journal={Trends in genetics : TIG},
  volume={29 3},
Recent surveillance data of multidrug-resistant tuberculosis (MDR-TB) reported the highest rates of resistance ever documented. As further amplification of resistance in MDR strains of Mycobacterium tuberculosis occurs, extensively drug-resistant (XDR) and totally drug-resistant (TDR) TB are beginning to emerge. Although for the most part, the epidemiological factors involved in the spread of MDR-TB are understood, insights into the bacterial drivers of MDR-TB have been gained only recently… CONTINUE READING
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