The heterochromatin loss model of aging

  title={The heterochromatin loss model of aging},
  author={Bryant Villeponteau},
  journal={Experimental Gerontology},

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

Results suggest that epigenetic preservation of genome stability, especially at the rDNA locus, and repression of unnecessary rRNA synthesis, might be an evolutionarily conserved mechanism for prolonging lifespan.

Chromatin structure and transposable elements in organismal aging

This review summarizes the recent evidence linking chromatin structure and function to aging, with a particular focus on the relationship of heterochromatin structure to organismal aging.

H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner

Overall, this work suggests that the heterochromatin loss model of ageing may be too simplistic an explanation of organismal ageing when molecular and tissue-specific effects are taken into account.

Roles of Topoisomerases in Heterochromatin, Aging, and Diseases

It is proposed that topological stress may be generated in both DNA and RNA during heterochromatin formation and function, which depend on multiple topoisomerases to resolve.

The Epigenome of Aging

The role of epigenetic modulators in DNA damage response pathway as well as heterochromatin formation and the alterations effected by these modulators on the epigenome during aging are focused on.

Sir2 links chromatin silencing, metabolism, and aging.

A speculative model of how a gradual disruption in chromatin silencing may occur and how such a change may cause aging is presented, which is widely observed in many organisms.

Breaking the aging epigenetic barrier

This review focuses on genomic and epigenomic changes occurring in an aged cell which can contribute to age-related tumor formation.

Erratum to: Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence

The results showed that the two genes neuropeptide Y (Npy) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes, there was gradual increase in cell viability along with restoration of the expression of Topo IIβ and potential repair proteins.

The great unravelling: chromatin as a modulator of the aging process.




Heterochromatin and gene expression in Drosophila.

The models and experimental data that address the mechanisms of PEV in different cell types, the potential functions of modifiers ofPEV, and the relationship of PEv to other phenomena associated with variegated gene expression in Drosophila are evaluated.

Position effect variegation and chromatin proteins

  • Gunter ReuteP. Spierer
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1992
PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components and demonstrates that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin Components and hence to fundamental aspects of chromosome structure and function.

Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae.

Changes in silencing in the URA3 gene raise the possibility that the transcriptional status of genes in the subtelomeric region may be important for the senescence of both dividing cells and postmitotic cells, in which telomeres remain constant in length.

Cell lineage‐specific expression of modulo, a dose‐dependent modifier of variegation in Drosophila.

Based on its dominant phenotype, expression pattern and DNA‐binding activity of its product, it is proposed that mod regulates chromatin structure and activity in specific cell lineages.

A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants.

Modifiers of position-effect-variegation in Drosophila encode proteins that are thought to modify chromatin, rendering it heritably changed in its expressibility. In an attempt to identify similar

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

The discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals are reported, establishing new connections between silencing and these fundamental cellular processes.