The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter.

@article{AlShawi1991TheHS,
  title={The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter.},
  author={Raya Al-Shawi and John Burke and H. D. Wallace and Claire Jones and Stephen Harrison and David Buxton and Stephen W Maley and Ann C. Chandley and John O. Bishop},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 8},
  pages={4207-16}
}
We reported previously that the herpes simplex virus type 1 (HSV-1) thymidine kinase reporter gene (tk) was expressed in the testes of transgenic mice when coupled to the promoter of a liver-specific mouse major urinary protein (MUP) gene. Here we show that HSV-1 tk is also expressed in the testis when coupled to a MUP pseudogene promoter, to a truncated MUP promoter that is not active in the liver, and to the promoter of the bovine thyroglobulin gene. Furthermore, HSV-1 tk itself was expressed… CONTINUE READING

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Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency.

Proceedings of the National Academy of Sciences of the United States of America • 1989
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