The herpes simplex virus type 1 alkaline nuclease is not essential for viral DNA synthesis: isolation and characterization of a lacZ insertion mutant.

@article{Weller1990TheHS,
  title={The herpes simplex virus type 1 alkaline nuclease is not essential for viral DNA synthesis: isolation and characterization of a lacZ insertion mutant.},
  author={Sandra K Weller and Mohamad Seghatoleslami and L Shao and D Rowse and Eleanor Carmichael},
  journal={The Journal of general virology},
  year={1990},
  volume={71 ( Pt 12)},
  pages={2941-52}
}
Herpes simplex virus type 1 (HSV-1) encodes a novel enzyme activity, the alkaline nuclease, whose precise role in the viral replication cycle remains obscure. The alkaline nuclease gene corresponds to the UL12 open reading frame, which is predicted to encode a protein of 626 amino acid residues. We describe the isolation and characterization of a null mutant of the gene for the viral alkaline nuclease in which 917 bp from the N-terminal half of the gene (corresponding to residues 70 to 375… CONTINUE READING
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DNA sequence

  • D. J. McGEOCH, A. DOLAN, M. C. FRAME
  • 1986
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Herpes simplex virus type 1 DNA synthesis requires the product of the LIL8 gene : isolation and characterization of an ICP6::IacZ insertion mutation

  • K.S.
  • Journal of Virology 63, 591-599.
  • 1989

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