The herpes simplex virus ribonucleotide reductase is required for ocular virulence.

Abstract

We used a herpes simplex virus (HSV) type 1 ribonucleotide reductase (RR) null mutant (ICP6 delta) to study the role of HSV-1 RR in ocular HSV infections. We found that ICP6 delta was unable to induce vascularization of the cornea or stromal keratitis following inoculation into the cornea of BALB/c mice, but was able to induce a transient mild blepharitis… (More)

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Cite this paper

@article{Brandt1991TheHS, title={The herpes simplex virus ribonucleotide reductase is required for ocular virulence.}, author={Curtis R. Brandt and Randall L Kintner and Anne M Pumfery and Robert J. Visalli and Dorene R. Grau}, journal={The Journal of general virology}, year={1991}, volume={72 ( Pt 9)}, pages={2043-9} }