The herpes simplex virus 2 virion-associated ribonuclease vhs interferes with stress granule formation.

@article{Finnen2014TheHS,
  title={The herpes simplex virus 2 virion-associated ribonuclease vhs interferes with stress granule formation.},
  author={Ren{\'e}e L. Finnen and Thomas J. M. Hay and Bianca Dauber and James R. Smiley and Bruce W. Banfield},
  journal={Journal of virology},
  year={2014},
  volume={88 21},
  pages={12727-39}
}
UNLABELLED In a previous study, it was observed that cells infected with herpes simplex virus 2 (HSV-2) failed to accumulate stress granules (SGs) in response to oxidative stress induced by arsenite treatment. As a follow-up to this observation, we demonstrate here that disruption of arsenite-induced SG formation by HSV-2 is mediated by a virion component. Through studies on SG formation in cells infected with HSV-2 strains carrying defective forms of UL41, the gene that encodes vhs, we… CONTINUE READING
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