The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth

@article{Wu2015TheHO,
  title={The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth},
  author={Wilfred W. Wu and David J. Witherspoon and Alison Fraser and Erin A. S. Clark and Alan Rogers and Gregory J. Stoddard and Tracy Ann Manuck and Karin Chen and Michael Sean Esplin and Ken Smith and Michael W. Varner and Lynn B. Jorde},
  journal={Human Genetics},
  year={2015},
  volume={134},
  pages={803-808}
}
Preterm birth (PTB), defined as birth prior to a gestational age (GA) of 37 completed weeks, affects more than 10 % of births worldwide. PTB is the leading cause of neonatal mortality and is associated with a broad spectrum of lifelong morbidity in survivors. The etiology of spontaneous PTB (SPTB) is complex and has an important genetic component. Previous studies have compared monozygotic and dizygotic twin mothers and their families to estimate the heritability of SPTB, but these approaches… CONTINUE READING
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Genetics and analysis of quantitative traits

  • M Lynch, B Walsh
  • 1998
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