The heritability of Dupuytren's disease: familial aggregation and its clinical significance.

@article{Hindocha2006TheHO,
  title={The heritability of Dupuytren's disease: familial aggregation and its clinical significance.},
  author={Sandip Hindocha and Sally John and John K. Stanley and Stewart J Watson and Ardeshir Bayat},
  journal={The Journal of hand surgery},
  year={2006},
  volume={31 2},
  pages={204-10}
}
PURPOSE Dupuytren's disease (DD) is a benign, fibroproliferative disease affecting the hands. The familial occurrence of DD and its presence in identical twins suggests a genetic basis for the condition. Our aims in this study were (1) to provide evidence for familial aggregation of DD by estimating the sibling recurrence-risk ratio and (2) to link previously associated environmental risk factors with family history of DD. METHODS Patients diagnosed with DD between the ages of 58 and 81 years… CONTINUE READING

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