The heritability and genetics of frontotemporal lobar degeneration.

  title={The heritability and genetics of frontotemporal lobar degeneration.},
  author={Jonathan D. Rohrer and Rita L Guerreiro and Jana Vandrovcova and J Bradford Uphill and David M Reiman and J Beck and Adrian M. Isaacs and Astrid Authier and Raffaele Ferrari and Nick C. Fox and Ian R Mackenzie and Jason D Warren and Rajith De Silva and J. Jerome Holton and Tamas R Revesz and John S. Hardy and Simon Mead and Martin Rossor},
  volume={73 18},
BACKGROUND Frontotemporal lobar degeneration (FTLD) is a genetically and pathologically heterogeneous neurodegenerative disorder. METHODS We collected blood samples from a cohort of 225 patients with a diagnosis within the FTLD spectrum and examined the heritability of FTLD by giving each patient a family history score, from 1 (a clear autosomal dominant history of FTLD) through to 4 (no family history of dementia). We also looked for mutations in each of the 5 disease-causing genes (MAPT… CONTINUE READING
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