The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.

@article{Gemmill1998TheHR,
  title={The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.},
  author={Robert M Gemmill and John D. West and Ferenc Boldog and Noritaka Tanaka and Leanne J. Robinson and David I. Smith and Feng Li and Harry A. Drabkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 16},
  pages={
          9572-7
        }
}
  • Robert M Gemmill, John D. West, +5 authors Harry A. Drabkin
  • Published in
    Proceedings of the National…
    1998
  • Biology, Medicine
  • The 3;8 chromosomal translocation, t(3;8)(p14.2;q24.1), was described in a family with classical features of hereditary renal cell carcinoma. Previous studies demonstrated that the 3p14.2 breakpoint interrupts the fragile histidine triad gene (FHIT) in its 5' noncoding region. However, evidence that FHIT is causally related to renal or other malignancies is controversial. We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to… CONTINUE READING

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