The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications.

@article{Chung2003TheHN,
  title={The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications.},
  author={Daniel C. Chung and Anil K Rustgi},
  journal={Annals of internal medicine},
  year={2003},
  volume={138 7},
  pages={
          560-70
        }
}
In the United States, an individual's lifetime risk for developing some form of cancer is estimated to be as high as 40% (1). Cancer is fundamentally a genetic disorder, meaning that mutations in specific genes confer a selective growth advantage for tumor cells. Such mutations may develop sporadically or may be inherited through the germline, which results in a hereditary predisposition to multiple cases of early-onset cancer. Identification of these cancer-susceptibility genes has revealed… CONTINUE READING

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