The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment.

@article{Bhatt2007TheHH,
  title={The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment.},
  author={Lavinia Bhatt and Conor P. Horgan and Melanie Walsh and Mary W. McCaffrey},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={359 2},
  pages={277-84}
}
Hereditary Hemochromatosis is an iron overload disease most frequently associated with mutations in the HFE gene. While clinical studies of the disease have received extensive attention by various groups, the localisation, trafficking and function of the HFE protein, and its chaperone beta2-microglobulin (beta2M), require further investigation. In this study, we present data on the cellular localisation of HFE and its clinically relevant mutants in HuTu 80 cells. We find by confocal microscopy… CONTINUE READING