The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells.

@article{Ikeda2006TheHM,
  title={The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells.},
  author={Hitoshi Ikeda and Kayo Nagashima and Mikio Yanase and Tomoaki Tomiya and Masahiro Arai and Yukiko Inoue and Kazuaki Tejima and Takako Nishikawa and Naoko Watanabe and Kazuya Kitamura and Tomomi Isono and Naohisa Yahagi and Eisei Noiri and Mie Inao and Satoshi Mochida and Yukio Kume and Yutaka Yatomi and Kazuhiko Nakahara and Masao Omata and Kenji Fujiwara},
  journal={Life sciences},
  year={2006},
  volume={78 19},
  pages={2226-33}
}
Use of herbal remedies in the treatment of various diseases has a long tradition in Eastern medicine and the liver diseases are not an exception. In their use, lack of elucidation of mechanism(s) as well as randomized, placebo-controlled clinical trials has been a problem. Recently, we and others reported that inchin-ko-to (TJ-135), one of herbal remedies, suppressed hepatic fibrosis in animal models. In the course of clarifying the mechanism, we directed our focus on hepatic stellate cells… CONTINUE READING