The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site.

@article{Song2006TheHC,
  title={The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site.},
  author={Yutong Song and Peter Friebe and Eleni Tzima and Christiane Juenemann and Ralf Bartenschlager and Michael Niepmann},
  journal={Journal of virology},
  year={2006},
  volume={80 23},
  pages={
          11579-88
        }
}
The positive-strand RNA genome of the hepatitis C virus (HCV) is flanked by 5'- and 3'-untranslated regions (UTRs). Translation of the viral RNA is directed by the internal ribosome entry site (IRES) in the 5'-UTR, and subsequent viral RNA replication requires sequences in the 3'-UTR and in the 5'-UTR. Addressing previous conflicting reports on a possible function of the 3'-UTR for RNA translation in this study, we found that reporter construct design is an important parameter in experiments… CONTINUE READING

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