The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C.

@article{Luber1993TheHB,
  title={The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C.},
  author={Birgit Luber and Ulrich M. Lauer and Ludwig Weiss and Marina Hoehne and P. H. Hofschneider and Alexander S Kekul{\'e}},
  journal={Research in virology},
  year={1993},
  volume={144 4},
  pages={311-21}
}
Chronic infection with hepatitis B virus (HBV) is accompanied by an increasing risk of developing hepatocellular carcinoma. There are indications that the HBx protein of HBV is involved in the process of tumour formation. HBx also transactivates several transcription factor binding sites. Recently, we reported that HBx can use a tumour promotor pathway for transactivation. In particular, we found that transactivation of the binding motif for transcription factor AP-1 (JUN/FOS) by HBx is… CONTINUE READING

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