The hepatitis B pX protein promotes dimerization and DNA binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region.

@article{Perini1999TheHB,
  title={The hepatitis B pX protein promotes dimerization and DNA binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region.},
  author={Giovanni Perini and Elke Oetjen and Martin R. Green},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 20},
  pages={13970-7}
}
The hepatitis B virus pX protein is a potent transcriptional activator of viral and cellular genes whose mechanism of action is poorly understood. Here we show that pX dramatically stimulates in vitro DNA binding of a variety of cellular proteins that contain basic region/leucine zipper (bZIP) DNA binding domains. The basis for increased DNA binding is a… CONTINUE READING