The hepatic glycogenoreticular system

  title={The hepatic glycogenoreticular system},
  author={G{\'a}bor B{\'a}nhegyi and József Mandl},
  journal={Pathology Oncology Research},
One of the major liver functions is the ability of hepatocytes to store glucose in the form of glycogen for various purposes. Beside glucose production and secretion, the synthesis of glucuronides and ascorbate has been reported to be dependent on the extent of the glycogen stores and on the rate of glycogenolysis in the liver. It is common that the final steps of these pathways are catalysed by intraluminially orientated enzymes of the endoplasmic reticulum, which are supported by transporters… 
The ER – Glycogen Particle – Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy?
The physiological significance, molecular logic and regulation of the two different catabolic paths are summarized and discussed with special aspect on the role of glycogen particles in intracellular organelle homeostasis and on molecular pathology of the cell.
Vitamin C: update on physiology and pharmacology
The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for asCorbate in the treatment of various diseases.
Antioxidant Compounds from Vegetable Matrices: Biosynthesis, Occurrence, and Extraction Systems
This work aimed to give a comprehensive overview on the occurrence of these antioxidants in plants, in particular in plant foods, on the mechanisms of biosynthesis, and on conventional and innovative extraction systems.
Fermentation and germination improve nutritional value of cereals and legumes through activation of endogenous enzymes
Traditional fermentation and germination processes are presented as a means to address myriad interactions through activation of endogenous enzymes such as α‐amylase, pullulanase, phytase, and other glucosidases to break down complex macronutrients to their simple and more digestible forms.
Development of Antioxidant and Nutritious Lentil (Lens culinaris) Flour Using Controlled Optimized Germination as a Bioprocess
RSM optimization of germination temperature and time using desirability function revealed that the optimal process conditions to maximize the nutritional, bioactive and quality properties of sprouted lentil flours were 21 °C for 3.5 days.
Effects of pre-slaughter ascorbic acid administration on some physiological stress response and meat quality traits of lambs and kids subjected to road transport
The present study determined the effects of pre-slaughter ascorbic acid administration on some physiological indicators and meat quality traits of road transport-stressed lambs and kids. Eighteen
Comparative Studies on the In Vitro Antioxidant and Antimicrobial Properties of Methanolic And Hydro-Ethanolic Plant Extracts from Five Medicinal Plant Parts of Ghana
A Thesis Submitted to the Department Of Chemistry, College of Science and the School Of Graduate Studies, Kwame Nkrumah University of Science and Technology In Partial Fulfilment of the Requirement


Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes.
It is demonstrated that hepatic glucose release does not require the presence of GLUT2 nor of any plasma membrane glucose facilitative diffusion mechanism, which implies the existence of an as yet unsuspected pathway for glucose release that may be based on a membrane traffic mechanism.
Demonstration of a Metabolically Active Glucose-6-phosphate Pool in the Lumen of Liver Microsomal Vesicles*
It is concluded that liver microsomes take up glucose- 6-phosphate, constituting a pool directly accessible to intraluminal glucose-6-ph phosphatase activity, confirming the existence of separate transport proteins.
Glucose-6-phosphatase (D-glucose-6-phosphate phosphohydrolase; EG is unique among gluconeogenic enzymes in a variety of respects. Not only is the enzyme either a part of, or extremely
Regulation of glucuronidation by glutathione redox state through the alteration of UDP-glucose supply originating from glycogen metabolism.
Results suggest that alteration of the GSH/GSSG ratio regulates glucuronidation by affecting enzymes of the glycogen metabolism via the modification of UDP-glucuronate supply.
It is indicated that glucose-6-phosphatase develops simultaneously within all of the rough endoplasmic reticulum membranes of a given cell, although asynchronously in the hepatocyte population as a whole.
Fine structure of hepatocytes from fasted and fed rats.
It is concluded that SER is associated with glycogen particles in rat hepatocytes during both deposition and depletion of glycogen.