The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination

@article{Pethe2001TheHH,
  title={The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination},
  author={K{\'e}vin Pethe and S. Sevilla Alonso and Franck Biet and Giovanni Delogu and Michael James William Brennan and Camille Locht and Franco Menozzi},
  journal={Nature},
  year={2001},
  volume={412},
  pages={190-194}
}
Tuberculosis remains the world's leading cause of death due to a single infectious agent, Mycobacterium tuberculosis, with 3 million deaths and 10 million new cases per year1. The infection initiates in the lungs and can then spread rapidly to other tissues2. The availability of the entire M. tuberculosis genome sequence3 and advances in gene disruption technologies4 have led to the identification of several mycobacterial determinants involved in virulence5,6,7,8. However, no virulence factor… CONTINUE READING
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