The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.

@article{Xi2013TheHD,
  title={The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.},
  author={Gang Xi and Melissa A Solum and Christine Y Y Wai and Laura A. Maile and Clifford J. Rosen and David Robert Clemmons},
  journal={Endocrinology},
  year={2013},
  volume={154 11},
  pages={4146-57}
}
IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains 2 heparin-binding domains (HBD), which are localized in the linker region (HBD1) and C-terminal region (HBD2) of IGFBP-2. To determine the relative importance of these domains, we used synthetic… CONTINUE READING