The heparan sulfate proteoglycan agrin modulates neurite outgrowth mediated by FGF-2.

@article{Kim2003TheHS,
  title={The heparan sulfate proteoglycan agrin modulates neurite outgrowth mediated by FGF-2.},
  author={Min Jung Kim and Susan L Cotman and Willi M Halfter and Gregory J Cole},
  journal={Journal of neurobiology},
  year={2003},
  volume={55 3},
  pages={261-77}
}
Although the role of agrin in the formation of the neuromuscular junction is well established, other functions for agrin have remained elusive. The present study was undertaken to assess the role of agrin in neurite outgrowth mediated by the heparin-binding growth factor basic fibroblast growth factor (FGF-2), which we have shown previously to bind to agrin with high affinity and that has been shown to mediate neurite outgrowth from a number of neuronal cell types. Using both an established… CONTINUE READING

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