The hemoglobin derived peptide LVV-hemorphin-7 evokes behavioral effects mediated by oxytocin receptors.

@article{Cruz2017TheHD,
  title={The hemoglobin derived peptide LVV-hemorphin-7 evokes behavioral effects mediated by oxytocin receptors.},
  author={Kellen Rosa da Cruz and Larissa C{\'o}rdova Turones and Gabriel Camargo-Silva and Karina Pereira Gomes and Michelle Mendanha Mendonça and Pablinny Moreira Galdino and Christielly Rodrigues-Silva and Robson Augusto Souza Santos and Elson A Costa and Paulo C{\'e}sar Ghedini and Danielle Ianzer and Carlos Henrique Xavier},
  journal={Neuropeptides},
  year={2017},
  volume={66},
  pages={
          59-68
        }
}
LVV-hemorphin-7 (LVV-h7) is bioactive peptide resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which displays oxytocinase activity. Herein, our aims were to assess whether: i) LVV-h7 modifies centrally organized behavior and cardiovascular responses to stress and ii) mechanisms underlying LVV-h7 effects involve activation of oxytocin (OT) receptors… CONTINUE READING