The hemoglobin-deficit mouse: cure of the anemia following bone marrow transplantation with normal marrow.

Abstract

The hemoglobin-deficit mouse mutant (hbd) is characterized by a severe microcytic anemia that is inherited in an autosomal-recessive manner. Previous results from our laboratory indicated that normal mice develop anemia if they are transplanted with bone marrow from mutant animals. Furthermore, we demonstrated a delay in erythroid reconstitution from hbd… (More)

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