The hemoglobin E thalassemias.

  title={The hemoglobin E thalassemias.},
  author={Suthat Fucharoen and David J. Weatherall},
  journal={Cold Spring Harbor perspectives in medicine},
  volume={2 8}
Hemoglobin E (HbE) is an extremely common structural hemoglobin variant that occurs at high frequencies throughout many Asian countries. It is a β-hemoglobin variant, which is produced at a slightly reduced rate and hence has the phenotype of a mild form of β thalassemia. Its interactions with different forms of α thalassemia result in a wide variety of clinical disorders, whereas its coinheritance with β thalassemia, a condition called hemoglobin E β thalassemia, is by far the most common… CONTINUE READING
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