The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs.

  title={The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs.},
  author={Jacqueline Shaffer and Fa-Yauh Lee and Scott Thomson and Byung Joon Han and John P Cooke and Joseph Loscalzo},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={256 2},
We studied the effects of a unique vasoactive agent, S-nitrosocaptopril (SnoCap), in an anesthetized canine preparation. We have previously demonstrated that this agent manifests the properties of both a direct nitrovasodilator and an angiotensin-converting enzyme inhibitor in vitro. The present investigation was performed to evaluate the effects of SnoCap in vivo. Intravenous administration of SnoCap produced immediate reductions in blood pressure and significantly attenuated the pressor… CONTINUE READING

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