The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.

@article{DAlessio2012TheHP,
  title={The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.},
  author={Flavia D'Alessio and Matthias W. Hentze and Martina U. Muckenthaler},
  journal={Journal of hepatology},
  year={2012},
  volume={57 5},
  pages={1052-60}
}
BACKGROUND & AIMS The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin. While the genetic interactions are clear, it remains elusive how bone morphogenetic protein co-receptor HJV functions together with HFE and TfR2 to activate hepcidin transcription via the BMP-SMAD signaling pathway. Here, we investigate whether HFE, TfR2, and HJV physically interact on the surface of hepatocytes. METHODS We… CONTINUE READING
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