The hemizona assay (HZA): development of a diagnostic test for the binding of human spermatozoa to the human hemizona pellucida to predict fertilization potential.

@article{Burkman1988TheHA,
  title={The hemizona assay (HZA): development of a diagnostic test for the binding of human spermatozoa to the human hemizona pellucida to predict fertilization potential.},
  author={Lani Johnson Burkman and Charles C. Coddington and Daniel Rossouw Franken and T F Krugen and Zev Rosenwaks and Guido Hogen},
  journal={Fertility and sterility},
  year={1988},
  volume={49 4},
  pages={688-97}
}
The authors present their initial results with the hemizona assay (HZA), which was developed to predict the fertilizing potential of spermatozoa. The HZA uses the matching halves of a human zona pellucida from a nonfertilizable and nonliving oocyte, providing an internal control on zona-to-zona variability. Maximal binding of human sperm to the hemizona usually occurred after 4 to 5 hours of coincubation. Sperm from fertile men exhibited significantly higher binding capacity to hemizonae… CONTINUE READING

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