The heme-binding lipoprotein (HbpA) of Haemophilus influenzae: role in heme utilization.

@article{Morton2005TheHL,
  title={The heme-binding lipoprotein (HbpA) of Haemophilus influenzae: role in heme utilization.},
  author={Daniel J. Morton and Larissa L Madore and Augustine Joseph Smith and Timothy Michael Vanwagoner and Thomas W. Seale and Paul W. Whitby and Terrence L. Stull},
  journal={FEMS microbiology letters},
  year={2005},
  volume={253 2},
  pages={
          193-9
        }
}
Haemophilus influenzae has an absolute growth requirement for heme and a heme binding lipoprotein (HbpA) has been implicated in the utilization of this essential nutrient. HbpA was identified by examining clones from an H. influenzae genomic library that caused Escherichia coli harboring the clone to bind heme. However, HbpA has not been shown to mediate heme acquisition in H. influenzae. We constructed an insertional mutation of hbpA in a nontypeable H. influenzae strain and demonstrated a… CONTINUE READING
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