The hematopoietic factor GM-CSF (Granulocyte-macrophage colony-stimulating factor) promotes neuronal differentiation of adult neural stem cells in vitro

@article{Krger2007TheHF,
  title={The hematopoietic factor GM-CSF (Granulocyte-macrophage colony-stimulating factor) promotes neuronal differentiation of adult neural stem cells in vitro},
  author={Carola Kr{\"u}ger and Rico Laage and Claudia Pitzer and Wolf R{\"u}diger Sch{\"a}bitz and Armin Schneider},
  journal={BMC Neuroscience},
  year={2007},
  volume={8},
  pages={88 - 88}
}
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotective in animal stroke models. The GM-CSF receptor α is expressed on adult neural stem cells in the rodent brain, and in culture. Addition of GM-CSF to NSCs in vitro increased neuronal… CONTINUE READING
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