The helical model of the nucleosome core.

  title={The helical model of the nucleosome core.},
  author={Edward N. Trifonov},
  journal={Nucleic acids research},
  volume={5 4},
A model of the nucleosome core is proposed based on a topologically linear array of histones attached sequentially to DNA. The linear complex folds helically forming a spring-like particle. Different variants of the particle are discussed (cylindrical springs with and without histone-histone contacts between turns of the helix, solenoidal spring). The model is consistent with known data about the nucleosome structure. Histones H3 and H4 have a special role in the model which is related also to… CONTINUE READING