The hedgehog signaling network

  title={The hedgehog signaling network},
  author={M. Michael Cohen},
  journal={American Journal of Medical Genetics Part A},
  • M. Cohen
  • Published 15 November 2003
  • Biology
  • American Journal of Medical Genetics Part A
In the hedgehog signaling network, mutations result in various phenotypes, including, among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall syndrome, Greig cephalopolysyndactyly, Rubinstein‐Taybi syndrome, isolated basal cell carcinoma, and medulloblastoma. Active Hedgehog ligand is double lipid modified with a C‐terminal cholesterol moiety and an N‐terminal palmitate. Transport active Hedgehog from the signaling cell to the responding cell occurs through three… 

Hedgehog signaling update.

  • M. Cohen
  • Biology
    American journal of medical genetics. Part A
  • 2010
In vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via

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smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

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Patched acts catalytically to suppress the activity of Smoothened

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