The hedgehog pathway and neurological disorders.

  title={The hedgehog pathway and neurological disorders.},
  author={Tammy L. Dellovade and Justyna T Romer and Tom Curran and Lee L Rubin},
  journal={Annual review of neuroscience},
The hedgehog pathway is a major regulator of embryonic development, and mutations that decrease its activity are known to be associated with severe defects in nervous system development. Recent evidence suggests hedgehog continues to function in adult tissue, normal as well as diseased, by regulating both cell proliferation and the production of growth and angiogenic factors. In the adult nervous system, this dual ability is especially important in regulating the behavior of neural stem and… CONTINUE READING