The heavy metal ions Ag+ and Hg2+ trigger calcium release from cardiac sarcoplasmic reticulum.

@article{Prabhu1990TheHM,
  title={The heavy metal ions Ag+ and Hg2+ trigger calcium release from cardiac sarcoplasmic reticulum.},
  author={Sumanth D. Prabhu and Guy Salama},
  journal={Archives of biochemistry and biophysics},
  year={1990},
  volume={277 1},
  pages={47-55}
}
Heavy metal ions have been shown to induce Ca2+ release from skeletal sarcoplasmic reticulum (SR) by binding to free sulfhydryl groups on a Ca2+ channel protein and are now examined in cardiac SR. Ag+ and Hg2+ (at 10-25 microM) induced Ca2+ release from isolated canine cardiac SR vesicles whereas Ni2+, Cd2+, and Cu2+ had no effect at up to 200 microM. Ag(+)-induced Ca2+ release was measured in the presence of modulators of SR Ca2+ release was compared to Ca2(+)-induced Ca2+ release and was… CONTINUE READING