The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells.

Abstract

Recent studies have suggested that the proliferation of malignant gliomas may result from activation of protein kinase C (PKC)-mediated pathways. Enzastaurin (LY317615), an acyclic bisindolylmaleimide, is an oral inhibitor of PKCbeta as well as other isoforms. The initial objective of this study was to assess the efficacy of enzastaurin in a series of… (More)
DOI: 10.1016/j.canlet.2008.03.039

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@article{Jane2008TheHS, title={The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells.}, author={Esther P. Jane and Ian F Pollack}, journal={Cancer letters}, year={2008}, volume={268 1}, pages={46-55} }