The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.

@article{Haug2005TheHS,
  title={The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.},
  author={Markus Haug and Luciana Dannecker and Carsten P Schepp and William W Kwok and Dorothee Wernet and Jane H Buckner and Hubert Kalbacher and Guenther E. Dannecker and Ursula Holzer},
  journal={European journal of immunology},
  year={2005},
  volume={35 11},
  pages={3163-72}
}
Heat shock proteins (HSP) can interact with a wide variety of peptides and the resulting HSP:peptide complexes are known to be highly immunogenic. The ability of HSP:peptide complexes to elicit CD8+ T cell responses by cross-presentation of exogenous antigen via MHC class I is well known. In contrast, their role in the activation of CD4+ T cells is less clearly defined, although several recent studies in mice and T cell lines suggest an involvement of HSP in the presentation of antigenic… CONTINUE READING
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