The heat shock protein Gp96 links innate and specific immunity.

  title={The heat shock protein Gp96 links innate and specific immunity.},
  author={Norbert Hilf and Harpreet Singh-Jasuja and Hansjoerg Schild},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  volume={18 6},
Among other heat shock proteins (HSPs), the ER-resident chaperone Gp96 has been described as a potent tumour vaccine in animal models. A growing list of data underlines that Gp96 triggers both arms of pathogen defence-innate and specific immunity-in a synergistic and most efficient way: It enables specific immune responses by transferring immunogenic peptides that have been acquired in the ER to the MHC class I pathway of antigen presenting cells (APCs). For this, two important features of Gp96… CONTINUE READING
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