The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions.

@article{Radsak2003TheHS,
  title={The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions.},
  author={Markus P Radsak and Norbert Hilf and Harpreet Singh-Jasuja and Sibylla Braedel and Peter Brossart and Hans-Georg Rammensee and Hansjoerg Schild},
  journal={Blood},
  year={2003},
  volume={101 7},
  pages={2810-5}
}
The endoplasmic reticulum (ER)-resident heat shock protein Gp96 is involved in protein folding and is released into the extracellular space after necrotic cell death. In this context, Gp96 has immunostimulatory properties: it activates dendritic cells or macrophages and delivers associated peptides into the antigen presentation pathway, resulting in the induction of specific T-cell responses. The inflammatory response after necrotic tissue damage leads to the recruitment of polymorphonuclear… CONTINUE READING
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