The heat shock protein 70 molecular chaperone network in the pancreatic endoplasmic reticulum - a quantitative approach.

@article{Weitzmann2007TheHS,
  title={The heat shock protein 70 molecular chaperone network in the pancreatic endoplasmic reticulum - a quantitative approach.},
  author={Andreas Weitzmann and Christiane Baldes and Johanna Dudek and Richard Zimmermann},
  journal={The FEBS journal},
  year={2007},
  volume={274 19},
  pages={5175-87}
}
Traditionally, the canine pancreatic endoplasmic reticulum (ER) has been the workhorse for cell-free studies on protein transport into the mammalian ER. These studies have revealed multiple roles for the major ER-luminal heat shock protein (Hsp) 70, IgG heavy chain-binding protein (BiP), at least one of which also involves the second ER-luminal Hsp70, glucose-regulated protein (Grp) 170. In addition, at least one of these BiP activities depends on Hsp40. Up to now, five Hsp40s and two… CONTINUE READING