The heat shock paradox: does NF-kappaB determine cell fate?

  title={The heat shock paradox: does NF-kappaB determine cell fate?},
  author={SUSAN. L. DeMEESTER and Timothy G. Buchman and J. Perren Cobb},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={15 1},
Cellular injury induces an adaptive response whether the insult is physical (e.g., heat, radiation), chemical (e.g., reactive oxygen species), infectious (e.g., bacteria), or inflammatory (e.g., lipopolysaccharide). Recent data indicate that the interactions of these responses are not predictable and that sequence permutations can have opposite effects on outcome after injury. Our overarching hypothesis is that interactions among stress responses contribute to the fate of cells, tissues, and… CONTINUE READING


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