The heart and estrogen/progestin replacement study revisited: hormone replacement therapy produced net harm, consistent with the observational data.

@article{Blakely2000TheHA,
  title={The heart and estrogen/progestin replacement study revisited: hormone replacement therapy produced net harm, consistent with the observational data.},
  author={Jeffrey A. Blakely},
  journal={Archives of internal medicine},
  year={2000},
  volume={160 19},
  pages={2897-900}
}
Lower coronary event rates in women receiving hormone replacement therapy (HRT) have led to a presumption of benefit. The Heart and Estrogen/Progestin Replacement Study, a large randomized trial, observed a 1.4% first year excess of coronary events, well beyond the plausible play of chance on the expected effect. Over the duration of the study, event totals were similar, but patients treated with HRT experienced them earlier, with a net loss of patient-months of event-free survival. The point… CONTINUE READING

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