The heart: an end-organ of GH action.

  title={The heart: an end-organ of GH action.},
  author={Annamaria Colao and Giovanna Vitale and Rosario Pivonello and Antonio Ciccarelli and Carolina Di Somma and Gaetano Lombardi},
  journal={European journal of endocrinology},
  volume={151 Suppl 1},
Several experimental and clinical studies have indicate that the heart is an end-organ of GH action. Patients with either childhood- or adulthood-onset GH deficiency (GHD) have abnormalities of cardiac structure and function, such as reduced cardiac mass, impaired diastolic filling and reduced left ventricular response at peak exercise. These cardiovascular abnormalities can be reversed, at least partially, after GH replacement therapy. On the other hand, the chronic overproduction of GH and… CONTINUE READING
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