The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease.

@article{Kowalczyk1999TheHD,
  title={The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease.},
  author={Andrew Kowalczyk and Mechthild Hatzfeld and Elayne A. Bornslaeger and Dr. S. Kopp and Jeffrey E. Borgwardt and Connie Marie Corcoran and A Settler and Kathleen Janee Green},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 26},
  pages={18145-8}
}
The contribution of desmosomes to epidermal integrity is evident in the inherited blistering disorder associated with the absence of a functional gene for plakophilin-1. To define the function of plakophilin-1 in desmosome assembly, interactions among the desmosomal cadherins, desmoplakin, and the armadillo family members plakoglobin and plakophilin-1 were examined. In transient expression assays, plakophilin-1 formed complexes with a desmoplakin amino-terminal domain and enhanced its… CONTINUE READING
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